Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)
Ahmedabad-Ahmedabad-380001, Gujarat, India
Company
o2h Group
Job Description
Peptide Chemist:
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Plan and execute solid-phase and solution-phase peptide synthesis (SPPS/LPPS) using automated synthesizers such as Syro and CEM Liberty Blue
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Independently handle peptide synthesis across scales from gram to 1 kg, with troubleshooting abilities
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Purify and characterize peptides using preparative HPLC, analytical HPLC, LC-MS, and MS
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Operate, calibrate, and maintain lab equipment to keep synthesis workflows running smoothly
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Maintain compliance with laboratory safety and SHE (Safety, Health & Environment) standards
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Review relevant literature to inform synthetic strategy and troubleshooting approaches
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Keep accurate, timely experimental records (lab notebooks, batch records, ELN entries as applicable)
High Potent APIs (HPAPI):
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Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.
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Execute chemical reactions, work-ups, purification and related laboratory processes.
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Handle HPAPIs in accordance with applicable safety, containment and handling procedures.
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Maintain accurate laboratory records, experimental data and documentation.
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Support process development, optimization and troubleshooting activities.
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Perform analytical sample preparation and coordinate with analytical teams as required.
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Follow established GMP, EHS and laboratory safety requirements.
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Support investigation and resolution of laboratory/process-related issues.
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Where required, support chemistry activities related to ADC and highly potent payloads.
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Work effectively with cross-functional teams including analytical and other chemistry groups.
Organic Chemist:
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Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance
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Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography
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Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations
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Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately
Scaleup Chemist:
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Experience in process R&D, scale-up synthesis, and purification from gm to kg scale
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Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities
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Proficient in 1H NMR, HPLC, and LCMS interpretation
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Strong project execution and team collaboration skills
Antibody Drug Conjugation Chemist (ADC)
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Synthesis and purification of complex antibody drug conjugate (ADC) molecules
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Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs
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Synthesis of highly potent drug molecules – payloads
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Purification of complex and large molecules by flash column and HPLC
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Handling various type chemistry with different payloads
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Interpretation and characterisation of higher molecular weight compounds
Requirements
Peptide Chemist:
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M.Sc. or M.Pharm in Organic Chemistry, Medicinal Chemistry
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2–4 years of hands-on experience in peptide synthesis
Principal Scientist;
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PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.
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Strong experience in CRO/CDMO research environment.
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Proven team management experience with exposure to handling multiple projects.
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Excellent communication and client-facing skills.
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Ability to drive productivity, scientific excellence, and team development.
Organic Chemist:
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Master’s in Organic Chemistry with 1-3 years of experience in the CRO Industry
Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.
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Proactive, highly motivated with a "can do" attitude
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Exceptional interpersonal skills.
Peptide/Scaleup/Antibody Drug Conjugation (ADC) Chemist:
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Master’s in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry
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Adherence to safe practices and procedures
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Contribution to the development of safety protocols and systems
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Must be able to prioritize and organize work responsibilities in order to meet deadlines